• Sebum production in seven hirsute women was found to be markedly inhibited by low-dosage glucocorticoid therapy, usually 5 to 10 mg of prednisone daily, combined with the cyclic administration of ethinyl estradiol, either 80μg or 100μg daily, in the form of oral contraceptive medication. The average reduction of sebum secretion was 85.7%, from a pretreatment mean value of 3.07 mg of sebum to an average treatment level of 0.44 mg.
(Arch Dermatol 112:1108-1109, 1976)
Pochi PE, Strauss JS. Sebaceous Gland Inhibition From Combined Glucocorticoid-Estrogen Treatment. Arch Dermatol. 1976;112(8):1108-1109. doi:10.1001/archderm.1976.01630320018003