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August 1976

Corticosteroid-Induced Cutaneous Atrophy and TelangiectasiaExperimental Production Associated With Weight Loss in Rats

Author Affiliations

From the Department of Dermatology, Medical College of Georgia, Augusta. Mr. Wehr is now with the Armour-Dial Research Center, Scottsdale, Ariz.

Arch Dermatol. 1976;112(8):1115-1117. doi:10.1001/archderm.1976.01630320025006

• A bioassay for the evaluation of certain adverse effects of various corticosteroids was performed. Twenty-eight daily topical applications of corticosteroids to young rats produced reduction in body-weight gain, atrophy of the skin as determined by double skin-fold thickness micrometer measurement, and mild to severe telangiectasia. This animal model demonstrates corticosteroid-induced skin atrophy and telangiectasia and the correlation of the degree of atrophy and telangiectasia to body-weight change. Nine corticosteroids were evaluated by this method and are listed in terms of increasing severity of side-effects as follows: 1.0% hydrocortisone cream, 0.1% betamethasone valerate cream, 0.025% betamethasone benzoate cream, 0.05% flurandrenolide cream, 0.05% fluocinonide cream, 0.1% dexamethasone cream, and 0.03% flumethasone pivalate cream. Triamcinolone acetonide cream, 0.5%, and 0.2% fluocinolone acetonide cream resulted in death of the animals prior to completion of 28 days of topical application.

(Arch Dermatol 112:1115-1117, 1976)