We describe a patient with a painful lytic lesion of the clavicle and a granuloma of the liver in late secondary syphilis. The classic "moth-eaten" alopecia of the scalp as well as eyebrows and eyelashes suggested syphilis, although an initial false-negative VDRL test for syphilis (prozone phenomenon) caused a delay in diagnosis. Bone as well as liver involvement in early syphilis may be more common than previously recognized.
(Arch Dermatol 112:1451-1454, 1976)
Longstreth P, Hoke AW, Mc Elroy C. Hepatitis and Bone Destruction as Uncommon Manifestations of Early SyphilisReport of a Case. Arch Dermatol. 1976;112(10):1451-1454. doi:10.1001/archderm.1976.01630340069020