To the Editor.—
Normolipemic plane xanthoma is an uncommon skin disease that has been associated with a variety of reticuloendothelial diseases. The hitherto undescribed association of this condition and diffuse histiocytic lymphoma has been observed in a recent patient admitted at the Christie Hospital, Manchester, England.
Report of a Case.—
A 45-year-old man had a two-year history of a reddish-brown indurated eruption on his shoulders, arms, forehead, and periorbital tissue. Skin biopsy supported the clinical diagnosis of diffuse xanthomatosis, and lipid studies disclosed normolipemic values (fasting serum cholesterol, 2.5 millimols/liter; serum chylomicron, < 0.1 millimol/liter; serum lipoprotein, 1.2 millimols/liter). Three months later, he developed osteolytic lesions in the left ischium and the upper portion of the left femur. On admission, a mass was palpable on the left side of the pelvis and the left leg was edematous, but there was no lymphadenopathy or splenomegaly. Laboratory studies disclosed the following results:
Haqqani MT, Hunter RD. Normolipemic Plane Xanthoma and Histiocytic Lymphoma. Arch Dermatol. 1976;112(10):1470-1471. doi:10.1001/archderm.1976.01630340082033