• A 21-year-old woman with eventually fatal malignant atrophic papulosis (Degos disease) was treated primarily with the fibrinolytic agents phenformin hydrochloride and ethylestrenol. In spite of therapy, primarily central nervous system manifestations led to the patient's death.
(Arch Dermatol 112:1582-1588, 1976)
Howsden SM, Hodge SJ, Herndon JH, Freeman RG. Malignant Atrophic Papulosis of DegosReport of a Patient Who Failed to Respond to Fibrinolytic Therapy. Arch Dermatol. 1976;112(11):1582-1588. doi:10.1001/archderm.1976.01630350056015