To the Editor.—
Yeckley et al1 recently hypothesized that the morphological characteristics of Sezáry cells are merely the result of nonspecific stimulation of lymphocytes. This hypothesis is based on the observation that phytohemagglutinin (PHA) and pokeweed mitogen induced the production of Sezáry-like cells from normal human lymphocytes. The presence of Sezáry-like cells in a variety of inflammatory dermatoses2 supports this interpretation.This observation, however, does not exclude the possibility that malignant cells or cells that have been transformed by virus may also manifest Sezáry-cell morphological features. Also, it does not provide an explanation of the apparently malignant cytogenetic abnormalities observed in Sezáry cells.3,4In the process of a trial to produce a human lymphocyte cell line infected with Epstein-Barr (EB) virus, we observed a line of cells that showed a morphological similarity to Sezáry cells. There Sezáry-like cells were morphologically distinct from the Burkitt lymphoma cell line.
Noguchi S, Robinowitz BN. Sezáry-like Cells From Supernatant of Burkitt Lymphocyte Cell Culture. Arch Dermatol. 1976;112(11):1612-1613. doi:10.1001/archderm.1976.01630350078025