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Article
December 1976

Systemic Lupus Erythematosus: A Clinical Analysis, Major Problems in Internal Medicine-Volume VI

Author Affiliations

San Francisco

 

by James F. Fries, MD, and Halsted R. Holman, MD, 199 pp, illus, $14, WB Saunders Co, 1975.

Arch Dermatol. 1976;112(12):1805. doi:10.1001/archderm.1976.01630370075025

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Abstract

This monograph is a study of 187 patients with systemic lupus erythematosus (SLE) whose cases were followed at Stanford University Hospital by the authors. It is short, concise, and informative. The authors have used computer science techniques to analyze their data and to determine prognosis and management.

Examples of computer-provided correlations that demonstrate the style of the book include the following: antibodies to ribonucleoprotein (RNP) and Sm antigen identify serologic subsets of patients that appear to be rather homogeneous. Patients with antibody to RNP have Raynaud phenomena, less renal disease, normal serum complement, and rarely antibody to DNA. Patients with antibody to DNA have an increase in the frequency of pleuritic episodes. Pleurisy is not only associated with renal disease but often predicts a renal exacerbation. The ANA is of little value in predicting prognosis or therapy. Profound thrombocytopenia is ominous and frequently is associated with death in a few

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