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Article
January 1977

Chronic Bullous Dermatosis of Childhood

Author Affiliations

From the Department of Pediatrics, Michael Reese Hospital and Medical Center (Drs Esterly, Kirschner, and Kretschmer), and the Department of Dermatology, Northwestern University Medical School (Dr Furey), Chicago.

Arch Dermatol. 1977;113(1):42-46. doi:10.1001/archderm.1977.01640010044005
Abstract

• The clinical features, laboratory studies, and therapeutic responses of two boys with chronic bullous dermatosis of childhood are described. Direct immunofluorescent preparations of sections from a lesion, skin adjacent to a lesion, and uninvolved skin demonstrated linear deposition of IgA at the dermoepidermal junction in all three biopsy specimens from one patient. Similar preparations from the second child were negative for staining. No circulating antibodies to skin components were detected in either child by means of multiple substrates. Neither child had clinical manifestations nor laboratory findings suggestive of an associated gastrointestinal lesion; therefore, small bowel biopsies were not performed. Immunologic studies failed to demonstrate any of the abnormalities frequently described in dermatitis herpetiformis. Both boys responded dramatically to sulfapyridine therapy.

(Arch Dermatol 113:42-46, 1977)

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