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Article
February 1977

Cutaneous Manifestations of Wegener Granulomatosis

Author Affiliations

From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1977;113(2):175-182. doi:10.1001/archderm.1977.01640020047008
Abstract

• In a series of 19 patients (15 male and 4 female) who had Wegener granulomatosis with specific cutaneous histopathologic findings, the skin was only involved at onset in two. Four distinct histologic subgroups were defined as follows: necrotizing vasculitis (11 patients); necrotizing palisading granuloma (Churg-Strauss lesion) (2 patients); granulomatous vasculitis (2 patients); and lymphomatoid granulomatosis (4 patients). The 11 patients with necrotizing vasculitis had purpuric and hemorrhagic lesions, and the presence of vesicles and ulceration correlated with the severity of onset and extent of disease. The remaining eight patients had papular and nodular lesions. The patients with necrotizing vasculitis and lymphomatoid granulomatosis had a worse prognosis than did those with a predominant granulomatous reaction.

(Arch Dermatol 113:175-182, 1977)

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