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February 1977

Selective Uptake of Contact Allergens by the Langerhans Cell

Author Affiliations

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1977;113(2):187-192. doi:10.1001/archderm.1977.01640020059010

• Using histochemical staining techniques, it has been possible to demonstrate the selective uptake of ten different contact allergens by the Langerhans cells. It is postulated that the Langerhans cells form a reticuloepithelial system that clears the epidermis of foreign chemicals. The Langerhans cell is viewed as the site of hapten binding and antigen formation and hence the central target cell in immune contact dermatitis reactions.

(Arch Dermatol 113:187-192, 1977)