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March 1977

Gastrointestinal Absorption of Griseofulvin From Corn Oil-in-Water EmulsionsEffect of Amount of Corn Oil Ingested in Man

Author Affiliations

From the Department of Pharmaceutics, School of Pharmacy (Dr Bates and Mr Pieniaszek and Sequeira), and the Department of Dermatology, School of Medicine (Dr Rasmussen), State University of New York at Buffalo.

Arch Dermatol. 1977;113(3):302-306. doi:10.1001/archderm.1977.01640030048006

• The effect of the amount of emulsified corn oil ingested on the gastrointestinal absorption of griseofulvin in man was assessed after oral administration of 5, 10,15, or 30 gm doses of a corn oil (40% w/w)-in-water emulsion dosage form, each containing 250 mg of microsize griseofulvin. For comparison, griseofulvin absorption from two-125 mg commercial tablets of ultramicrosize drug dispersed in polyethylene glycol 6,000 was also determined. Griseofulvin was almost completely absorbed from the microsize drug emulsions and ultramicrosize drug tablets, whereas 50% of an oral dose is absorbed from commercial microsize griseofulvin tablets. Only 4 gm of emulsified corn oil (as a 10-gm dose of emulsion) is required to maximize the uniformity and extent of griseofulvin absorption. The emulsion dosage form is uniquely suited for pediatric use.

(Arch Dermatol 113:302-306, 1977)