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March 1977

Serum IgE in Dermatitis and DermatosisAn Analysis of 497 Cases

Author Affiliations

From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1977;113(3):309-315. doi:10.1001/archderm.1977.01640030055008

• Serum IgE values from 497 patients with various forms of dermatitis, dermatosis, and tinea pedis were analyzed statistically and compared with values from 95 normal controls. The median and geometric mean values were significantly elevated (except in acne without atopy, lichen planus, and tinea pedis), even after exclusion of patients with a history of atopy or of cutaneous reaction to food or drugs. Serum IgE levels and atopic dermatitis have a close correlation. A modest positive correlation (p ≅ .05) appeared between the log serum IgE level and peripheral blood absolute eosinophil count in 80 cases of atopic dermatitis. A unique group of adult nonatopic patients had acquired generalized dermatitis and markedly elevated serum IgE levels (> 12,000 ng/ml). Our results suggest that, in most common dermatologic disorders, elevated serum IgE is a secondary phenomenon rather than a primary causative factor.

(Arch Dermatol 113:309-315, 1977)