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April 1977

Topical Chemotherapy and Immunotherapy of Mycosis FungoidesIntermediate-Term Results

Author Affiliations

From the Skin and Cancer Hospital, Department of Dermatology, Temple University School of Medicine (Drs Vonderheid; Van Scott; Johnson; and Grekin), and the Department of Radiation Therapy and Nuclear Medicine, Hahne mann Medical College and Hospital of Philadelphia (Dr Asbell), Philadelphia.

Arch Dermatol. 1977;113(4):454-462. doi:10.1001/archderm.1977.01640040062009

• A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years. Response to treatment, immunologic responsiveness, and subsequent course and survival were inversely related to magnitude of disease at time of starting treatment. Relapses were common, and in most instances were related to failure of maintenance of topical therapy rather than to drug resistance. In selected patients topical therapy with an analog of mechlorethamine (nor-mechlorethamine) and with topical immunogenic agents provided additional improvement.

(Arch Dermatol 113:454-462, 1977)