• Erythermalgia is a distinctive clinical entity characterized by local redness, warmth, and burning pain in the distal portions of the extremities. In this study, erythermalgia was observed in two patients with myeloproliferative disease. A new theory suggesting abnormally rapid platelet aggregation as a cause of erythermalgia was advanced. The following evidence is presented: (1) histologic evidence of thrombi occluding the arterioles and probably composed of platelet aggregates; (2) reversal of the clinical findings with platelet aggregating drugs, such as heparin sodium and acetylsalicylic acid; (3) disappearance of the erythermalgia with the adequate control of the myeloproliferative disease.
(Arch Dermatol 113:468-471, 1977)
Redding KG. Thrombocythemia as a Cause of Erythermalgia. Arch Dermatol. 1977;113(4):468-471. doi:10.1001/archderm.1977.01640040076011