[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.120.181. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1977

Mixed Connective Tissue Disease SyndromeCutaneous Manifestations of Patients With Epidermal Nuclear Staining and High Titer Serum Antibody to Ribonuclease-Sensitive Extractable Nuclear Antigen

Author Affiliations

From the Division of Dermatology, Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas. Dr Prystowsky is now at the Letterman Army Institute of Research, San Francisco.

Arch Dermatol. 1977;113(5):583-587. doi:10.1001/archderm.1977.01640050043002
Abstract

• Fifteen patients with epidermal nuclear staining on direct immunofluorescence of normal skin and high titer serum antibody to ribonuclease-sensitive extractable nuclear antigen (ENA) had diffuse nonscarring and focal alopecia, abnormal pigmentation, swollen hands with sclerodactyly, and chronic cutaneous lupus erythematosus (LE) as the most common dermatologie features. Direct immunofluorescence of normal, unexposed skin revealed a particulate ("speckled") epidermal nuclear staining pattern in all 15 patients and subepidermal immunoglobulin deposits in 5. Ribonucleoprotein antibodies in high titer are associated with this characteristic type of epidermal nuclear staining. These findings provide easily detectable markers for a less aggressive subset of LE characterized by distinctive clinical and laboratory features consistent with mixde connective tissue disease.

(Arch Dermatol 113:583-587, 1977)

First Page Preview View Large
First page PDF preview
First page PDF preview
×