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May 1977

Chloracne From Manufacture of a New Herbicide

Author Affiliations

From the Section of Industrial Dermatology, Department of Dermatology, Cleveland Clinic Foundation and Cleveland Clinic Educational Foundation, Ohio (Drs Taylor and Wuthrich), and Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, New York (Dr Poland). Dr Lloyd is in private practice in Youngstown, Ohio.

Arch Dermatol. 1977;113(5):616-619. doi:10.1001/archderm.1977.01640050076010

• Forty-one chemical company workers had chloracne as a result of exposure to 3,4,3',4'-tetrachloroazoxybenzene (TCAB), an extraneous intermediate produced during the manufacture of a new herbicide. There was no laboratory evidence of significant hepatotoxicity or porphyria during the short time the herbicide was produced. An acnegenic when applied to the rabbit ear, TCAB is also a potent inducer of the microsomal enzyme aryl hydrocarbon hydroxylase. Prevention of chloracne is a difficult industrial engineering task and treatment of the disease is even more perplexing.

(Arch Dermatol 113:616-619, 1977)