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To the Editor.—
Macrocytosis has been reported as a side effect of hydroxyurea therapy in psoriatics. There have been no long-term follow-up reports of patients with psoriasis who were treated with hydroxyurea.Ten psoriatics treated with hydroxyurea six years previously were recalled for observation and blood studies. In eight patients, there was no macrocytosis. Two patients had macrocytosis; one of these patients was a chronic alcoholic and the other was taking hydroxyurea. It was thought that the macrocytosis was due to the alcoholism and current hydroxyurea medication in these patients. There was no evidence of folic acid or vitamin B12 deficiency. There were no long-term ill effects from hydroxyurea.
Leavell UW, DeSimone P, Reeder P. Macrocytosis and Hydroxyurea Therapy in Psoriatics. Arch Dermatol. 1977;113(5):683. doi:10.1001/archderm.1977.01640050143026