Bullous pemphigoid (BP) has been reported in association with malignant neoplasms of the urinary tract, lung, genitalia, breast, pancreas, gastrointestinal (GI) tract, skin, and lymphoreticular system.1 The course of BP usually does not parallel the course of the malignant neoplasm. The malignant neoplasm may be evident at the onset of BP or present as an incidental finding at postmortem examination.2
Carcinoembryonic antigen (CEA) levels greater than 2.5 ng/ml have been reported in serum samples from patients with pancreatic, colonic, rectal, gastric, mammary, and cervical malignant neoplasms, and in some leukemias.3 The presence of CEA correlates with a high incidence of proved malignant neoplasms and is an early indicator of clinically unrecognized recurrence.4
The purpose of this study was to determine the incidence of a malignant neoplasm in a large number of patients with BP using clinical as well as serologic evaluation.
Subjects and Methods
Ahmed AR, Chu TM, Provost TT. Bullous PemphigoidClinical and Serologic Evaluation for Associated Malignant Neoplasms. Arch Dermatol. 1977;113(7):969. doi:10.1001/archderm.1977.01640070103017