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August 1977

Keratinizing DermatosesCombined Data From Four Centers on Short-Term Topical Treatment With Tretinoin

Author Affiliations

From the Departments of Dermatology, Mayo Clinic, Rochester, Minn (Dr Muller); Cleveland Metropolitan General Hospital (Drs Belcher and Lochner) and Cleveland Clinic (Drs Roenigk and Miller), Cleveland; the College of Medicine, University of Illinois, Chicago (Dr Esterly); and the Department of Clinical Pharmacology, Hoffmann-La Roche Inc, Nutley, NJ (Dr Weissman).

Arch Dermatol. 1977;113(8):1052-1054. doi:10.1001/archderm.1977.01640080054004

• In four medical centers, 40 patients with keratinizing dermatoses were treated with topical tretinoin (vitamin A acid) 0.1% cream and salicylic acid 2% cream in a short-term, double-blind study. Tretinoin was the more effective treatment for several of the keratinizing dermatoses with the exception of palmar-plantar hyperkeratosis, for which it was not effective in the concentration and method of application used. The most striking clinical responses occurred in patients with lamellar ichthyosis and ichthyosis vulgaris. Local adverse reactions—chiefly pruritus, erythema, burning, excoriation, and irritation—were not severe and could be controlled by modification of the treatment regimen.

(Arch Dermatol 113:1052-1054, 1977)