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August 1977

Bands in Cellular Blue Nevus-Reply

Author Affiliations

Worcester, Mass

Asheville, NC

Arch Dermatol. 1977;113(8):1130. doi:10.1001/archderm.1977.01640080131033

In Reply.—  Our experience on the relationship between cellular blue nevus and nerves is different from that of Dr Bourland. We have observed invasion of nerves by cellular blue nevus cells. In fact, a cell containing melanosomes, indistinguishable from the nevus cells present outside the nerve, can be seen in the Figure (close to the banded structure in black rectangle in the uppermost part of the electron micrograph).1 This has also been reported by other workers, both in experimentally induced nevi in animals2 and humans.3In contrast to Dr Bourland's observations, ultrastructural evidence of degeneration of Schwann cells and axons was seen in almost every nerve within the cellular blue nevi of our three patients. Figure 1 in our report showed multiple layers of basement membrane surrounding a Schwann cell from a nerve within a cellular blue nevus. Such changes have been considered to result from repeated

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