September 1977

Recovery Processes During Regression of Plane Warts

Author Affiliations

From the Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan (Drs Takigawa, Tagami, Ogino, Imamura, and Ofugi), and the Department of Dermatology, Kurashiki Central Hospital, Kurashiki, Japan (Dr Watanabe).

Arch Dermatol. 1977;113(9):1214-1218. doi:10.1001/archderm.1977.01640090062006

• The regressing process of plane warts can be divided into two phases: initial changes of wart virus-infected cells that later result in degeneration of warts, and recovery phase in which degenerating warts are rejected from the level of the basal layer followed by regeneration of normal epidermal cells from the surrounding epidermis. Electron microscopic observations of recovery phase of wart regression showed (1) the epidermal lesion was clearly divided into degenerating wart possessing altered viruses and regenerating epidermis; (2) melanocytes were demonstrated in degenerating warts; and (3) a new granular layer was evident beneath regressing wart in late recovery. Throughout the recovery process, infiltration of lymphocytes and macrophages was observed only in regenerating epidermis.

(Arch Dermatol 113:1214-1218, 1977)