Basal cell carcinoma rarely metastasizes. In more than 60% of reported patients, only lymph nodal metastases were present; bony metastases occur in fewer than 17% of patients with metastatic basal cell carcinoma.1 In this report, we describe a patient with myelofibrosis secondary to bone marrow metastases from basal cell carcinoma.
Report of a Case
A 55-year-old man was admitted to the hospital in June 1976 with anorexia, dyspnea, weakness, and weight loss of gradual onset. He underwent chemosurgical excision of a superficial skin cancer of unknown histologic type over his right lower eyelid in 1959 and was symptom-free until 1965 when the skin ulcer recurred. It was surgically excised (Fig 1), but during the next 11 years, it recurred several times and required multiple curettages, electrodesiccations, and surgical resections. In January 1976, radical exenteration of the right eye and right radical maxillectomy and resection of the ethmoid sinus were
Jager RM, Weiner LJ, Howell RS. Basal Cell Carcinoma With Bony Metastases Producing Myelofibrosis. Arch Dermatol. 1977;113(9):1288-1289. doi:10.1001/archderm.1977.01640090136025