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LIDEX (fluocinonide) 0.05% Cream and Ointment TOPSYN (fluocinonide) 0.05% Gel Summary of prescribing information Description LIDEX cream 0.05%, LIDEX ointment 0.05% and TOPSYN gel 0.05% contain the active compound fluocinonide. Fluocinonide, which is the 21-acetate ester of fluocinolone acetonide, has the chemical formula 6α, 9α, -difluoro-11β, 16α, 17α, 21-tetrahydroxypregna-l,4-diene-3, 20-dione, cyclic 16,17-acetal with acetone 21-acetate. LIDEX cream contains fluocinonide in FAPG® cream, a specially formulated cream base consisting of stearyl alcohol, polyethylene glycol 6000, propylene glycol, 1, 2, 6-hexanetriol and citric acid. This white cream vehicle is greaseless, non-staining, anhydrous and completely water miscible. The base provides emollient and hydrophilic properties. In this formulation, the active ingredient is totally in solution. LIDEX ointment contains fluocinonide in a specially formulated ointment base consisting of Amerchol CAB (mixture of sterols and higher alcohols), white petrolatum, propylene carbonate and propylene glycol. It provides the occlusive and emollient effects desirable in an ointment. In
Society Transactions. Arch Dermatol. 1977;113(9):1306-1308. doi:10.1001/archderm.1977.01640090154058