• Eighteen patients with acne vulgaris used a hydroalcoholic solution of clindamycin hydrochloride topically. Serum samples were obtained and assayed for clindamycin; no evidence for systemic absorption was found. The clindamycin capsules used in this preparation contained insoluble fillers that may be removed by filtration without loss of in vitro antibacterial activity. This solution is stable for at least six months.
(Arch Dermatol 113:1390-1391, 1977)
Algra RJ, Rosen T, Waisman M. Topical Clindamycin in Acne VulgarisSafety and Stability. Arch Dermatol. 1977;113(10):1390-1391. doi:10.1001/archderm.1977.01640100068011