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October 1977

Scleroderma-like Changes in Chronic Graft vs Host Disease

Author Affiliations


From the Departments of Dermatology (Drs Spielvogel and Goltz), Pediatrics (Dr Kersey), Laboratory Medicine (Dr Kersey), and Pathology (Dr Kersey), University of Minnesota, Minneapolis.

Arch Dermatol. 1977;113(10):1424-1428. doi:10.1001/archderm.1977.01640100102020

† A case of chronic graft vs host disease had scleroderma-like skin changes. Clinical progression was from poikiloderma to scleroderma, and histopathological changes and results of direct immunofluorescence were noted. It is probable that both cell-mediated (T-cell) and humoral (B-cell) mechanisms contribute to the pathogenesis of the graft vs host reaction.

(Arch Dermatol 113:1424-1428, 1977)