Although basal cell carcinoma most frequently arises in sun-exposed areas of elderly people, certain disease processes are associated with the development of basal cell carcinoma. Examples of these processes are nevus sebaceum, xeroderma pigmentosa, and basal cell nevus syndrome. In this report, two cases are presented in which basal cell carcinoma developed over long-standing dermatofibromas.
Report of Cases
A 53-year-old woman was seen initially in the surgery service because of a nonpigmented, nonulcerated nodule of the right arm that had been present for most of her life. She wanted the lesion removed for cosmetic purposes. The specimen consisted of an elliptical fragment of skin with a dermal tumor. Microscopically, the dermal neoplasm was composed of interlacing bundles of uniform, plump fibroblasts with abundant collagen production. In addition to varying degrees of acanthosis, the overlying epidermis showed a superficiallyBasal cell carcinoma overlies dermatofibroma (case 1) (hematoxylin-eosin, original magnification
Bryant J. Basal Cell Carcinoma Overlying Long-standing Dermatofibromas. Arch Dermatol. 1977;113(10):1445-1446. doi:10.1001/archderm.1977.01640100123028