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October 1977

Porcine Dermis Dressings in Epidermolysis Bullosa

Author Affiliations

Leeds, England

Arch Dermatol. 1977;113(10):1456. doi:10.1001/archderm.1977.01640100134030

To the Editor.—  The management of the severe forms of epidermolysis bullosa is a task that requires the highest standard of nursing skills. Often the results, despite intense effort, are disappointing. We report a case of the lethalis variant of epidermolysis bullosa in which the denuded areas of skin were dressed with lyophilized porcine dermis (Ethicon Corethium 2). Unfortunately, the patient died owing to inhalation of vomit 12 days after the treatment began, and a full trial of this treatment was not possible. The results in the early stages were sufficiently encouraging, however, to prompt us to report this case.

Report of a Case.—  The patient, a girl, was born at 37 weeks' gestation. At birth, blistering was evident over the dorsum of both hands, and the fingernails were dystrophic. Epidermal loss was present around the umbilicus, the knees, and the lower legs. Three days after birth, 10% of the total skin surface area was affected (mainly over the lower limbs), and mucous membrane involvement of the mouth had occurred.

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