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November 1977

Photochemotherapy of Psoriasis Using Methoxsalen and SunlightA Controlled Study

Author Affiliations

From the Department of Dermatology (Drs Parrish, White, Fitzpatrick, and Mr Kingsbury), Harvard Medical School, Massachusetts General Hospital, Boston, the Institute of Dermatology (Dr White), Royal Prince Alfred Hospital, Sydney, Australia, and the Military Hospital (Dr Zahar), Taif, Saudi Arabia.

Arch Dermatol. 1977;113(11):1529-1532. doi:10.1001/archderm.1977.01640110049006

• Fifty-one patients with psoriasis were treated with oral methoxsalen and sunlight exposure. Twelve of these patients received either methoxsalen or placebo prior to whole-body exposure. The remainder were treated with methoxsalen and sunlight to one side of the body and sunlight alone to the other. The conventional dose of methoxsalen (0.6 mg/kg) was compared with a low dose (0.3 mg/ kg). Oral methoxsalen when used in the higher dose followed by sun exposure is an effective treatment for psoriasis. Accurate ultraviolet dosimetry is essential to avoid phototoxic burns. The advantages and disadvantages of solar photochemotherpy are discussed.

(Arch Dermatol 113:1529-1532, 1977)