• Two women had multiple subcutaneous nodules that showed features of multicentric reticulohistiocytosis (MR). Neither had joint symptoms. Both had a raised erythrocyte sedimentation rate, an immunoglobulin G paraproteinemia, and raised levels of nonhepatic serum alkaline phosphatase. The skin lesions have been followed up, using light and electron microscopy, immunoperoxidase, and histochemical methods. The material in the giant cells stained positively for γ heavy chain determinants: the light chain type in each case was that of the paraprotein. An attempt to reproduce the skin lesions in one patient by intradermal injection of her paraprotein failed.
(Arch Dermatol 113:1576-1582, 1977)
Rendall JRS, Vanhegan RI, Robb-Smith AHT, Bowers RE, Ryan TJ, Vickers HR. Atypical Multicentric Reticulohistiocytosis With Paraproteinemia. Arch Dermatol. 1977;113(11):1576-1582. doi:10.1001/archderm.1977.01640110096017