Alopecia areata is a disease of unknown origin with some degree of hereditary transmission. We have analyzed the HLA antigens1 in 47 unrelated Finnish patients with alopecia areata.
The series comprised of 22 women and seven men with alopecia areata. These patients had patchy alopecia of the scalp. Six men and eight women had alopecia totalis, ie, total hair loss of the scalp. Two men and two women had alopecia universalis, ie, hair loss of the entire body.
The HLA phenotype frequencies in the 47 patients and in a Finnish control population2 are shown in Table 1. The increase of HLA-B12 was significant (χ2 = 15.67, P = .000075, P = .0018 after the correction for the 24 HLA specificities, relative risk = 3.59).In the 29 patients with patchy alopecia areata, the association with HLA-B12 was even stronger (χ2 = 20.80, P = .0000051, P = .00012 after correction, relative risk
Kianto U, Reunala T, Karvonen J, Lassus A, Tiilikainen A. HLA-B12 in Alopecia Areata. Arch Dermatol. 1977;113(12):1716. doi:10.1001/archderm.1977.01640120084017