Tissue typing for 28 antigens of the HLA-A and HLA-B loci that used the microlymphocytotoxicity method described by Terasaki and McClelland1 was performed in 70 unrelated white patients with focal alopecia areata; all of them had a reversible, inflammatory form of circular loss of hair with atrophy and dystrophy of the hair matrix.
The observed deviations in HLA antigen frequencies in a group of patients with alopecia areata as shown in the Table are statistically not significant (probably due to the small number of patients investigated). However, these results might be of interest, since an elevated frequency of HLA-B8 is known to occur in several other diseases with immunologic components. An elevated frequency of HLA-A9 has been found in another skin disease of unknown origin, in atopic dermatitis.2
This study was supported by Deutsche Forschungsgemeinschaft grant Al 92/9 and Sonderforschungsbereich 37.
HLA Antigen Frequencies in Alopecia Areata
Kuntz BME, Selzle D, Braun-Falco O, Scholz S, Albert ED. HLA Antigens in Alopecia Areata. Arch Dermatol. 1977;113(12):1717. doi:10.1001/archderm.1977.01640120085018