Recurrent oral ulceration (ROU) is the most common disease that affects the oral mucosa, and more than 10% of the population may be affected.1 Much of the recent evidence suggests that ROU is associated with autoimmune responses to oral mucosa or to some cross-reacting antigens.2-5 This evidence and the frequency of a family history of ROU6 raised the possibility that susceptibility to ROU may be associated with HLA antigens.
A series of 100 patients with ROU was studied, and these patients were subdivided into three groups, according to the following criteria that were published previously7: minor aphthous ulcers (MiAU), major aphthous ulcers (MjAU),8 and herpetiform ulcers (HU).9 The results were compared with those obtained in 100 unaffected adult controls who gave no history of ROU. Preliminary family studies were performed to explore the possibility that susceptibility to ROU might segregate with HLA haplotypes.
Challacombe SJ, Batchelor JR, Kennedy LA, Lehner T. HLA Antigens in Recurrent Oral Ulceration. Arch Dermatol. 1977;113(12):1717-1719. doi:10.1001/archderm.1977.01640120085019