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December 1977

HLA Markers and Lymphocytotoxins in Lichen Planus

Author Affiliations

From the Hôpital Saint-Louis, Paris.

Arch Dermatol. 1977;113(12):1719-1720. doi:10.1001/archderm.1977.01640120087020

Susceptibility to some diseases in man is now obviously sometimes linked with the main HLA histocompatibility system.1 In this study we have looked for an association between HLA antigens and lichen planus (LP).

Material and Methods  Forty-three adults (20 women and 23 men with an age range of 30 to 65 years) were typed for 35 HLA antigens by the microlymphocytotoxicity method.2 The diagnosis of LP was established clinically and confirmed by the results of histologic examination; direct immunofluorescence showed globular deposits of immunoglobulins and complement clustering in the upper part of the dermis in 23 cases. The duration of the LP was less than one year in 42 patients and two years in one; the extent of the lesions was moderate in 35 patients and diffuse in eight. Mucous membrane involvement was present in 36 patients; nails were damaged in one. In all the cases, the LP

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