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December 1977

Immunotherapy for Leprosy-Reply

Author Affiliations

Los Angeles

Arch Dermatol. 1977;113(12):1731. doi:10.1001/archderm.1977.01640120099034

In Reply.—  We chose the phrase "deliberately mismatched leukocytes" for two reasons. Drs Lim, Fusaro, and Good1 indicated their awareness that the tests they used were incomplete measures of histocompatibility and that donor-recipient leukocyte incompatibility, in terms of histocompatibility antigens, was a virtual certainty. Indeed, one of the hypotheses offered by these investigators to explain their results depended on the presence of donor-recipient leukocyte incompatibility. Lim et al1 stated:Another attractive possibility is that the allogenic lymphocytes react against the host as in the initiation of a graft vs host reaction. Such a reaction can act as an adjunct to a vigorous immune response of the host's cells and substitute for a T-cell requirement in an immune response.We regret any ambiguity that arose from our choice of words.We thank Dr Fusaro for pointing out the work of Saha et al.2 To Dr Saha and his colleagues

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