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January 1978

Angioimmunoblastic LymphadenopathyA Generalized Lymphoproliferative Disorder With Cutaneous Manifestations

Author Affiliations

From the Departments of Dermatology (Dr Matloff) and Mallory Institute of Pathology (Dr Neiman), Boston University Medical Center.

Arch Dermatol. 1978;114(1):92-94. doi:10.1001/archderm.1978.01640130056016

• Angioimmunoblastic lymphadenopathy (AIBL) is a recently described, systemic disorder characterized by an excessive proliferation of transformed lymphocytes, possibly the result of chronic antigenic stimulation, frequently by drugs. Cutaneous involvement, usually in the form of a pruritic, generalized, maculopapular rash, occurs in about 40% of cases. We saw a patient with AIBL who had an unusual, primarily plaque- and nodular-type of skin involvement and who had been receiving drugs not previously reported as being associated with this disorder. Because cutaneous involvement is a frequent, presenting complaint, dermatologists should be able to recognize this unusual, clinicopathologic entity.

(Arch Dermatol 114:92-94, 1978)