[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 1978

Decreased T Cell Levels in Patients With Warts

Author Affiliations

From the Student Health Service (Drs Chretien and Esswein), and the Infectious Disease Service (Drs Chretien and Garagusi), Department of Medicine, Georgetown University, Washington, DC.

Arch Dermatol. 1978;114(2):213-215. doi:10.1001/archderm.1978.01640140031007

• Thymus-derived lymphocyte (T cell) levels were determined in 72 healthy patients who had viral warts, in 21 healthy patients who had been cured of warts from one to 15 years previously, and in 35 age-matched normal controls who had no history of warts.

The mean percentage of lymphocytes that formed rosettes with sheep erythrocytes was less in patients with warts and patients previously cured of warts than in normal controls (P < .001 and P < .001, respectively). The number of total T cells/ cu mm was decreased in untreated patients with warts (P < .01) but was normal in patients cured of warts for more than one year. In addition, the morphology of the rosettes in the two patient groups differed from the controls; 32% had small numbers of sheep erythrocytes bound loosely to T cells compared with a rosette of numerous erythrocytes closely adherent to the T cell in 91% of the controls.

The results suggest a defect of cellular immunity in many healthy patients with warts.

(Arch Dermatol 114:213-215, 1978)