• In three cases of generalized argyria, the degree of slate-gray cutaneous discoloration varied from barely perceptible to pronounced. Deposition of silver-containing granules in and around cutaneous adnexal structures was best seen with darkfield microscopy. Histochemical studies suggested that the granules consisted of silver sulfide. Indiscriminate use of currently available silver-containing medications can result in generalized argyria.
(Arch Dermatol 114:373-377, 1978)
Pariser RJ. Generalized ArgyriaClinicopathologic Features and Histochemical Studies. Arch Dermatol. 1978;114(3):373-377. doi:10.1001/archderm.1978.01640150009003