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March 1978

Generalized ArgyriaClinicopathologic Features and Histochemical Studies

Author Affiliations

From the Dermatology Services, Veterans Administration Hospital, and the Department of Dermatology, University of Miami (Fla) School of Medicine.

Arch Dermatol. 1978;114(3):373-377. doi:10.1001/archderm.1978.01640150009003

• In three cases of generalized argyria, the degree of slate-gray cutaneous discoloration varied from barely perceptible to pronounced. Deposition of silver-containing granules in and around cutaneous adnexal structures was best seen with darkfield microscopy. Histochemical studies suggested that the granules consisted of silver sulfide. Indiscriminate use of currently available silver-containing medications can result in generalized argyria.

(Arch Dermatol 114:373-377, 1978)