• Bilateral uveitis, poliosis, hypomelanosis, and alopecia (Vogt-Koyanagi-Harada syndrome) developed spontaneously in a 57-year-old woman following operation for metastatic malignant melanoma. She has been disease-free for 8½ years in spite of a highly unfavorable prognosis. Within the framework of current concepts of cell-mediated and humoral immunity in patients with malignant melanoma, activity of the host's immune system is postulated for the destruction of normal melanocytes in the skin, hair follicle, and uveal tract, as well as for the favorable outcome.
(Arch Dermatol 114:439-441, 1978)
Sober AJ, Haynes HA. Uveitis, Poliosis, Hypomelanosis, and Alopecia in a Patient With Malignant Melanoma. Arch Dermatol. 1978;114(3):439-441. doi:10.1001/archderm.1978.01640150075022