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To the Editor.—
As a follow-up to our short report, "Search for a Causal Agent of Psoriasis by Seroepidemiologic Methods," (Archives 113:1287-1288, 1977), we report the results of testing 24 psoriatic serums and 24 matched control serums for antibodies to antinuclear factor (ANF). With a 2% suspension of mouse liver nuclei as antigen and radioimmunoassay as our test system, we find that the psoriatic serum has less antibodies (P =.01 to.025 as determined by χ2 analysis with the Yates correction) than do the matched controls. This could be interpreted as ANF antibodies being removed from the serum of psoriasis patients as a result of complexing with an antigen of as yet undetermined nature. This finding supports the idea that psoriasis is an immunecomplex disease.
Ratner JJ, Smith KO. Seroepidemiologic Search for Cause of Psoriasis. Arch Dermatol. 1978;114(5):799. doi:10.1001/archderm.1978.01640170093030