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To the Editor.—
During the past few months, I have been using a solution of 5% lincomycin hydrochloride monohydrate in 70% isopropyl alcohol for selected cases of acne vulgaris. The papular and cystic lesions have responded to this medication, in the opinions of both the patients and myself. However, recently, in several cases numerous comedones were noted to have developed, after only several months of therapy. The extent of comedonal involvement was quite striking, and caused me to believe that the therapy might have been playing a role as a causative factor. I am most curious to know whether others have had a similar experience.
Nonproprietary Name and Trademark of Drug
Lincomycin hydrochloride monohydrate— Lincocin.
Scherzer JM. Curious Comedo Genesis. Arch Dermatol. 1978;114(5):799. doi:10.1001/archderm.1978.01640170093031