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June 1978

Pyoderma GangrenosumAbnormal Monocyte Function Corrected In Vitro With Hydrocortisone

Author Affiliations

From the Departments of Dermatology (Drs Norris, Weston, and Thorne) and Pediatrics (Dr Humbert), University of Colorado School of Medicine, Denver.

Arch Dermatol. 1978;114(6):906-911. doi:10.1001/archderm.1978.01640180040010

• A 34-year-old man with chronic active hepatitis and pyoderma gangrenosum demonstrated abnormalities in neutrophil and monocyte function. Monocytes from this man had diminished chemotaxis and bacterial phagocytosis. These functions were significantly improved in vitro after one hour of incubation of monocytes with 105 hydrocortisone. Neutrophil function was normal for bactericidal activity and phagocytosis, but neutrophil chemotaxis was diminished. A plasma inhibitor was not found to explain these phagocyte alterations.

(Arch Dermatol 114:906-911, 1978)