• In a double-blind controlled comparison that lasted eight weeks, tablets of zinc sulfate monohydrate, 411 mg total daily dosage, and a lactose placebo were administered orally to 22 male subjects with moderate acne. At the same time, levels of zinc were determined in serum and urine. There were no statistically significant differences in the lesion counts (papules, pustules, open comedones, and closed comedones) in the zinc-treated and lactose-treated cases, despite evidence in serum and urine of absorption of zinc. The data from this study indicate that oral zinc therapy has no early clinical effect on male patients with moderate acne.
(Arch Dermatol 114:1018-1020, 1978)
Orris L, Shalita AR, Sibulkin D, London SJ, Gans EH. Oral Zinc Therapy of AcneAbsorption and Clinical Effect. Arch Dermatol. 1978;114(7):1018-1020. doi:10.1001/archderm.1978.01640190006002