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July 1978

Lucio's Phenomenon and Diffuse Nonnodular Lepromatous Leprosy

Author Affiliations

From the Section of Dermatology, Department of Medicine, University of Southern California, School of Medicine, and the Department of Dermatology, Los Angeles County-University of Southern California Medical Center, Los Angeles.

Arch Dermatol. 1978;114(7):1023-1028. doi:10.1001/archderm.1978.01640190011004

• The records of ten patients with Lucio's phenomenon showed clinical and histopathological changes similar to those described by others. Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy. Lymphopenia associated with splenomegaly in three patients and glomerulonephritis in one patient were unexpected findings of unknown relevance.

(Arch Dermatol 114:1023-1028, 1978)