• Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.
(Arch Dermatol 114:1029-1030, 1978)
Solomon AE, Lowe NJ. Percutaneous Absorption in Experimental Epidermal Proliferation. Arch Dermatol. 1978;114(7):1029-1030. doi:10.1001/archderm.1978.01640190017005