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July 1978

Histopathology of Oral Lesions of Discoid Lupus ErythematosusA Review of 25 Cases

Author Affiliations

From the Department of Oral Medicine and Pathology, Harvard School of Dental Medicine, Boston (Dr Shklar), and the Division of Oral Medicine, Tufts University School of Medicine Boston, (Dr McCarthy).

Arch Dermatol. 1978;114(7):1031-1035. doi:10.1001/archderm.1978.01640190019006

• In a study of 25 oral biopsy specimens of lesions of chronic discoid lupus erythematosus, a characteristic and diagnostic histopathological pattern was confirmed, which consisted of parakeratosis, hydropic degeneration of stratum germinativum, collagen degeneration, and a lymphocytic infiltration in a perivascular orientation. It is suggested that more oral biopsies be used in the diagnosis of discoid lupus erythematosus because of the ease of oral mucosal biopsy technique and the absence of scarring and discomfort from oral biopsy lesions.

(Arch Dermatol 114:1031-1035, 1978)