• Persistent refractory alopecia areata in 26 patients was treated topically with dinitrochlorobenzene (DNCB). Sixteen patients have had excellent regrowth of hair; three patients could either not be initially sensitized or an adequate allergic contact dermatitis on the scalp did not develop. Two patients discontinued therapy within two months; hair growth did not develop in five patients despite an adequate trial. Augmentation of the T-lymphocyte pool via DNCB sensitization and challenge may become effective therapy for some patients with severe alopecia areata.
(Arch Dermatol 114:1036-1038, 1978)
Daman LA, Rosenberg EW, Drake L. Treatment of Alopecia Areata With Dinitrochlorobenzene. Arch Dermatol. 1978;114(7):1036-1038. doi:10.1001/archderm.1978.01640190024007