• A patient with the discoid lupus erythematosus and lichen planus overlap syndrome had profound depression of serum C4 concentration associated with substantial mixed cryoblobulinemia. A family study failed to disclose evidence of a familial hypocomplementemia, cryoglobulinemia, or a dermatologic condition. Immunoglobulin, but no complement, was detected at the site of the skin abnormality. This case illustrates an immune-complex disorder with a mixed cryoglobulinemia that is related to immunoglobulin deposition in the skin.
(Arch Dermatol 114:1039-1042, 1978)
Jamison TH, Cooper NM, Epstein WV. Lichen Planus and Discoid Lupus ErythematosusOverlap Syndrome Associated With Cryoglobulinemia and Hypocomplementemia. Arch Dermatol. 1978;114(7):1039-1042. doi:10.1001/archderm.1978.01640190027009