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August 1978

Incontinentia PigmentiEvidence for Both Neutrophil and Lymphocyte Dysfunction

Author Affiliations

From the Veteran's Administration Hospital and Division of Dermatology (Dr Jessen), Department of Medicine (Drs Jessen, Van Epps, and Goodwin), Department of Microbiology (Dr Van Epps), and the Department of Pediatrics (Dr Bowerman), University of New Mexico School of Medicine, Albuquerque.

Arch Dermatol. 1978;114(8):1182-1186. doi:10.1001/archderm.1978.01640200036009

• A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.

(Arch Dermatol 114:1182-1186, 1978)