• Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery.
Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a series of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect on granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommend that patients with cheilitis granulomatosa who are receiving combined triamcinolonesurgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence.
(Arch Dermatol 114:1203-1206, 1978)
Krutchkoff D, James R. Cheilitis GranulomatosaSuccessful Treatment With Combined Local Triamcinolone Injections and Surgery. Arch Dermatol. 1978;114(8):1203-1206. doi:10.1001/archderm.1978.01640200057015