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August 1978

Multiple Trichoepithelioma and Breast CarcinomaSimultaneous Appearance of Epithelioma Adenoides Cysticum and Infiltrating Lobular Carcinoma of the Breast

Author Affiliations

From the Department of Dermatology, Beilinson Medical Center, Tel Aviv University, Sackler School of Medicine, Petah Tikva, Israel.

Arch Dermatol. 1978;114(8):1230. doi:10.1001/archderm.1978.01640200082026

Trichoepitheliomas are classified as poorly differentiated hamartomas of the hair germ,1 and they occur as either solitary or multiple manifestations. In the latter instance they are designated as epithelioma adenoides cysticum (EAC) and may be familial, with an autosomal dominant mode of inheritance in which there is a lessened expressivity and penetrance in male persons.2

Headington3 states that there is no reported association of EAC with lesions in other organ systems. We describe a patient in whom there was a simultaneous appearance of EAC and infiltrating lobular carcinoma of the breast.

Report of a Case  A 38-year-old woman sought medical care because of the appearance of a lump in her right breast. At the same time, she noticed a few small, fleshy, pinkish-purple nodules on her upper lip. The lump in the breast was excised, and on histological examination proved to be an infiltrating lobular carcinoma (Fig

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